Signalling in the News – PTEN and its dual phosphatase activities
March 15th, 2012
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PTEN continues to be a hot topic with a Science Signaling paper from Tibarewal and coworkers describing their work isolating the lipid and protein phosphatase activities on gene expression effects and cell invasion . See the Editors comments and article here.
P. Tibarewal, G. Zilidis, L. Spinelli, N. Schurch, H. Maccario, A. Gray, N. M. Perera, L. Davidson, G. J. Barton, N. R. Leslie, PTEN Protein Phosphatase Activity Correlates with Control of Gene Expression and Invasion, a Tumor-Suppressing Phenotype, But Not with AKT Activity. Sci. Signal. 5, ra18 (2012).