Outgrowth of single oncogene-expressing cells from suppressive epithelial environments.
April 3rd, 2012
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Very interesting article in Nature describing how clonal evoluation of cancer cells involves evading the localized, restrictive environment. This study is important because it shows that other, potentially quiescent mutations to oncogenes could then become dominant once the cell translocates from its microenvironment.
Leung CT, Brugge JS. Nature. 2012 Feb 8;482(7385):410-3. Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.